Basigin binds CD98 complex

CD97hc is a multifunctional glycoprotein with a single transmembrane domain, is highly expressed on proliferating cells, and functions as a chaperone for transporters. CD98hc forms disulfide-bonded heterodimers with at least seven different light chains (SLC7A5-11) that serve as amino acid transporters. Covalent cross-linking, mass spectrometric protein identification, and co-immunoprecipitation shows selective CD147 association with CD98hc complex.

CD97hc是一种多功能糖蛋白，具有单个跨膜结构域，在增殖细胞中高度表达，并作为转运蛋白的伴侣蛋白发挥作用。CD98hc与至少七种不同的轻链（SLC7A5-11）形成二硫键连接的异源二聚体，这些轻链作为氨基酸转运蛋白。通过共价交联、质谱蛋白鉴定和共免疫沉淀技术，揭示了CD147与CD98hc复合物的选择性结合。