Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D26M) and NADPH

Protein Data Bank Japan2024-02-21 更新2026-03-21 收录

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Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D26M) and NADPH Descriptor: 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Liu, J, Anderson, A. Deposit date: 2008-09-04 Release date: 2009-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors Chem.Biol.Drug Des., 73, 2009

本数据集为光滑念珠菌（Candida glabrata）二氢叶酸还原酶（Dihydrofolate Reductase）与2,4-二氨基-5-[3-甲基-3-(3-甲氧基-5-(2,6-二甲基苯基)苯基)丙-1-炔基]-6-甲基嘧啶（UCP111D26M）及烟酰胺腺嘌呤二核苷酸磷酸（NADPH，全称二氢烟酰胺腺嘌呤二核苷酸磷酸，DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）形成的复合物。数据集描述项：5-[(3R)-3-(5-甲氧基-2',6'-二甲基联苯-3-基)丁-1-炔-1-基]-6-甲基嘧啶-2,4-二胺、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸。作者：Liu, J、Anderson, A. 入库日期：2008-09-04 发布日期：2009-08-18 最后修订日期：2024-02-21 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.11埃（Å）引用文献：《利用高分辨率晶体结构探究光滑念珠菌二氢叶酸还原酶的活性位点并合成新型抑制剂》，《Chem.Biol.Drug Des.》，第73卷，2009年

创建时间：

2008-09-04