Haplotype-resolved female and male genomes reveal sex-specific genomic regions and provide insights into thermal stress in Scapharca subcrenata

Integrated analyses of transcriptomic, proteomic and metabolomic data sets consistently highlights the crucial involvement of protein function and retinol metabolism pathways in the heat-resistant strain of S. subcrenata. These findings underscore the significance of these pathways in enabling the strain's ability to withstand high temperatures and adapt to heat stress. The haplotype-resolved female and male genomes and multiomics data presented in this study provide a solid foundation for investigating the molecular mechanisms of sex in S. subcrenata.