Expression profiling of small intestine neuroendocrine tumors identifies subclasses with clinical relevance, therapeutic target and biomarkers for prognosis

We sought to define the gene expression profiles of small intestine neuroendocrine tumors (SI-NETs) in order to identify clinically relevant subgroups of tumors, prognostic markers and novel targets for treatment. Genome-wide expression profiling was conducted on tumor biopsies from a cohort of 33 patients with metastatic SI-NETs and on 10 normal small intestine (SI) mucosa (controls).