Power analysis - impact of workflow and batch variation.

The mixed model methodology sensitivity was assessed with a resampling study on simulated control data where a signal as a proportion of the biological variation was added to construct a knockout group prior to statistical comparison. A: Impact of increasing batch noise, where the noise was a multiplier of 10% of the biological noise. Data shown are the output for simulated bone mineral density trait with a random workflow and a 0.05 significance threshold. B: Impact of workflow. Data shown are the output for the five workflows considered within this manuscript for a 0.05 significance threshold.