Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP

Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(3-chlorophenyl)-6-[2-(3-phenoxypropoxy)ethyl]pyrimidine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Vanichtanankul, J, Yoomuang, A, Taweechai, S, Saeyang, T, Yuvaniyama, J, Tarnchompoo, B, Yuthavong, Y, Kamchonwongpaisan, S. Deposit date: 2021-07-28 Release date: 2022-06-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17, 2022

刚地弓形虫（Toxoplasma gondii）二氢叶酸还原酶-胸苷酸合酶（TgDHFR-TS）与P40、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）以及2'-脱氧尿苷5'-单磷酸（dUMP）形成的复合物。描述符：2'-脱氧尿苷5'-单磷酸、5-(3-氯苯基)-6-[2-(3-苯氧基丙氧基)乙基]嘧啶-2,4-二胺、双功能二氢叶酸还原酶-胸苷酸合酶……作者：Vanichtanankul J、Yoomuang A、Taweechai S、Saeyang T、Yuvaniyama J、Tarnchompoo B、Yuthavong Y、Kamchonwongpaisan S。沉积日期：2021-07-28；发布日期：2022-06-29；最后修改日期：2023-11-29。实验方法：X射线衍射（2.67埃）。引用文献：《有效抑制剂结合刚地弓形虫二氢叶酸还原酶-胸苷酸合酶的结构洞察》，发表于《ACS化学生物学》（Acs Chem.Biol.），第17卷，2022年。