HCAR3 binds HCAR3 ligands

HCAR3 (GPR109B) is activated by 3-hydroxyoctanoic acid (3HO) (Ahmed et al. 2009) and nicotinic acid (niacin) (Wise et al. 2003). 3HO is an intermediate of fatty acid beta-oxidation. Under conditions of increased beta-oxidation flux, such as during starvation, under a ketogenic diet, or in patients with diabetic ketoacidosis, 3HO plasma concentrations are sufficient to activate the HCAR3 receptor (Costa et al. 1998, Jones et al. 2002, Ahmed et al. 2009).

HCAR3（GPR109B）受3-羟基辛酸（3HO）（Ahmed等，2009年）和烟酸（niacin）（Wise等，2003年）的激活。3HO是脂肪酸β-氧化的中间产物。在β-氧化通量增加的条件下，如饥饿、生酮饮食期间或糖尿病酮症酸中毒患者中，3HO血浆浓度足以激活HCAR3受体（Costa等，1998年，Jones等，2002年，Ahmed等，2009年）。