The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor

The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor Descriptor: (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, ... Authors: Eadsforth, T.C, Hunter, W.N. Deposit date: 2013-12-23 Release date: 2015-02-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Characterization of 2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl Ureido Based Inhibitors of Trypanosoma Brucei Fold and Testing for Antiparasitic Activity. J.Med.Chem., 58, 2015

本数据集为布氏锥虫（Trypanosoma brucei）N5,N10-亚甲基四氢叶酸脱氢酶-环水解酶（FolD）与NADP辅酶及抑制剂结合的晶体结构，抑制剂结构式为：(2S)-2-[[4-[[2,4-二氨基-6-氧代-1H-嘧啶-5-基]氨基甲酰氨基]苯基]羰基氨基]戊二酸；该数据集还涉及胞质型C-1-四氢叶酸合酶（C-1-TETRAHYDROFOLATE SYNTHASE），后续内容省略。作者：Eadsforth, T.C.、Hunter, W.N.；存档日期：2013-12-23；发布日期：2015-02-04；最后修改日期：2023-12-20；实验方法：X射线衍射（分辨率2.05 Å）；引用文献：《布氏锥虫FolD的2,4-二氨基-6-氧代-1,6-二氢嘧啶-5-基脲基类抑制剂的表征及抗寄生虫活性测试》，刊载于《J.Med.Chem.》2015年第58卷。