Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution

Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitotriosidase-1 Authors: Fadel, F, Zhao, Y, Cachau, R, Cousido-Siah, A, Ruiz, F.X, Harlos, K, Howard, E, Mitschler, A, Podjarny, A. Deposit date: 2014-10-02 Release date: 2015-07-08 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.101 Å) Cite: New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM. Acta Crystallogr.,Sect.D, 71, 2015

结合2.5mM几丁二糖的人壳三糖酶-1（Chitotriosidase-1）催化结构域的1.10 Å分辨率晶体结构。描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、壳三糖酶-1（Chitotriosidase-1）。作者：Fadel, F、Zhao, Y、Cachau, R、Cousido-Siah, A、Ruiz, F.X、Harlos, K、Howard, E、Mitschler, A、Podjarny, A。沉积日期：2014-10-02。发布日期：2015-07-08。最后修改日期：2024-10-23。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.101 Å）。引用文献：《人壳三糖酶（CHIT1）催化结构域的酶促机制新认知：基于原子分辨率X射线衍射与混合QM/MM方法》，发表于Acta Crystallogr., Sect. D, 71, 2015。