PICC catheter with Kitelock™ solution

This dataset comprises biochemical and hematological laboratory values collected from critically ill patients to evaluate the effect of Kitelock catheter lock solution on laboratory markers. The aim of this study is to determine the volume of blood that needs to be drawn before laboratory analyses are no longer influenced by residual Kitelock solution. The dataset supports research on identifying potential interference in laboratory values and establishing guidelines for accurate blood sampling after catheter locking.

Research Hypothesis:

This study hypothesizes that residual Kitelock catheter lock solution can influence specific biochemical and hematological laboratory markers. By determining the volume of blood that needs to be discarded before accurate lab analyses can be performed, the study aims to provide evidence-based recommendations for blood sampling in clinical practice.

Dataset Variables:

Identification of samples:

patient_ID - annonymous identifier of the patient
tube_order - order of draw of tubes 1 is the first tube, 5 is the last (reference) tube
tube_type - one of the 3 possible tubes (K3EDTA tube [denoted as K3EDTA]; Sodium citrate tube [denoted as Citrate]; Lithium heparin tube [denoted as LiHep]) or "exclude" if the patient was excluded from the study
note - the reason for excluding the patient from the study

Biochemical markers:

Alkaline phosphatase (S_ALP, µkat/L)
Total protein (S_PROT, g/L)
Albumin (S_ALB, g/L)
Urea (S_UREA, mmol/L)
Creatinine (S_KREA)
Sodium (S_Na, mmol/L)
Potassium (S_K, mmol/L)
Chloride (S_Cl, mmol/L)
Calcium (S_Ca, mmol/L)
Osmolality (S_OSM, mmol/kg)
Magnesium (S_Mg)
Qualitative hemolysis, chylomicrons, and icterus indicators (S_kHEM, S_kCHYL, S_kIKT)

Hematological markers:

Leukocytes (B_LEU, x 10⁹/L)
Erythrocytes (B_ERY, x 10¹²/L)
Hemoglobin (B_HGB, g/L)
Hematocrit (B_HCT, fraction of total)
Mean corpuscular volume (B_MCV, fL)
Mean corpuscular hemoglobin (B_MCH, pg)
Mean corpuscular hemoglobin concentration (B_MCHC, g/L)
Platelets (B_TRB, x 10⁹/L)
Red cell distribution width (B_RDW, fraction of total)
Mean platelet volume (B_MPV, fL)

Coagulation markers:

Activated partial thromboplastin time (P_APTT, s)
APTT ratio (P_APTR)
Prothrombin time (P_PT_s, s)
Prothrombin ratio (P_PT_R)
International normalized ratio (P_INR)
Thrombin clotting time (P_TC, s)
Thrombin clotting ratio (P_TC_R)
Fibrinogen (P_FB)

Data Collection and Interpretation:

The data were collected from routine laboratory tests conducted in an intensive care setting, with a focus on laboratory markers that can be influenced by ethylenediaminetetraacetic acid (EDTA), the main component of Kitelock catheter lock solution. By analyzing these markers, the study aims to determine the extent to which residual EDTA affects laboratory results and establish guidelines for appropriate blood sampling volumes.