Significant predictors of viral non-structural gene substitution rates.

For each ANCOVA analysis, the overall adjusted R2 () of the model is given along with the significant predictor variable (P<0.01) and its standardized coefficients (β) with 95% confidence intervals (CIs). In the first ANCOVA, the base levels were epithelial target cells, fecal-oral/respiratory transmission route, acute/persistent infection, species-specific host range, and dsRNA genome architecture. In the second ANCOVA, the base levels were neural target cells, bites/scratches transmission route, acute infection, order-specific host range, and (−)ssRNA genome architecture. In the third ANCOVA, the base levels were leukocyte target cells, respiratory/vertical transmission route, acute infection, family-specific host range, and (+)ssRNA genome architecture.