Crystal structure of NRas-G12D in complex with GDP and compound 13

Crystal structure of NRas-G12D in complex with GDP and compound 13 Descriptor: (4P)-4-{3-[(1R,5S,6r)-3-azabicyclo[3.1.0]hexan-6-yl]-1-cyclopropyl-7-fluoro-4-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl}-5-ethynyl-6-fluoronaphthalen-2-ol, CITRIC ACID, GTPase NRas, ... Authors: Johnson, T.A, Cross, J.B. Deposit date: 2025-09-02 Release date: 2026-02-25 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structure-Guided Development of NRAS G12D Inhibitors Based on a 5‐Azaindole Core. Acs Med.Chem.Lett., 17, 2026NRas-G12D与GDP及化合物13结合的复合物晶体结构 描述项：(4P)-4-{3-[(1R,5S,6r)-3-氮杂双环[3.1.0]己烷-6-基]-1-环丙基-7-氟-4-异丙基-1H-吡唑并[4,3-c]吡啶-6-基}-5-乙炔基-6-氟萘-2-醇、柠檬酸、GTP酶NRAS…… 作者：Johnson, T.A.、Cross, J.B. 保藏日期：2025-09-02 发布日期：2026-02-25 最后修改日期：2026-03-04 实验方法：X射线衍射（分辨率1.56埃） 引用文献：《基于5-氮杂吲哚母核的NRAS G12D抑制剂的结构导向开发》，《ACS药物化学快报》，17卷，2026年