PGxLOD

PGxLOD groups data related to pharmacogenomics (PGx) from various sources such as PharmGKB, DrugBank, ClinVar, DisGeNET, but also the scientific literature. Central elements of PGxLOD are pharmacogenomic relationships, which are n-ary relationships linking drugs, genetic factors and drug-response phenotypes. Such relationships state the atomic elements of knowledge in PGx, i.e., a patient with a specified genetic factor and being treated with a specified drug is likely to experience the specified drug-response phenotypes (such as an adverse effect, no effect, etc.). PGxLOD is developed in the ANR PractiKPharma project (http://practikpharma.loria.fr/).

PGxLOD 对来自多种来源的药物基因组学（PGx）相关数据进行了分组，包括 PharmGKB、DrugBank、ClinVar、DisGeNET 以及科学文献。PGxLOD 的核心要素是药物基因组学关系，这些关系是连接药物、遗传因素和药物反应表型的 n 元关系。此类关系阐述了药物基因组学知识的基本要素，即具有特定遗传因素的病人在接受特定药物治疗时，可能经历特定的药物反应表型（如不良反应、无反应等）。PGxLOD 是在 ANR PractiKPharma 项目（http://practikpharma.loria.fr/）中开发的。