An early paradoxical GH increase after glucose load characterises non-acromegalic patients with high IGF-1 levels

Objective: An incomplete GH suppression after oral glucose tolerance test (OGTT) is the hallmark of acromegaly diagnosis. A proportion of patients with acromegaly present a paradoxical GH rise (GH-Par) after glucose administration. We aimed to study if GH-Par response after glucose load can characterize patients without acromegaly.
Design: Observational case-control study in a referral centre.
Methods: We recruited patients with suspected acromegaly (n=176), characterized by increased IGF-1 levels (GH nadir >0.4 µg/L defined acromegaly), and 55 matched controls (normal IGF-1 and suppressed GH). GH-Par90min was defined as GH peak ≥120% over basal levels at latest 90 minutes after glucose intake.

研究目标：口服葡萄糖耐量测试（OGTT）后生长激素（GH）抑制不完全被视为肢端肥大症诊断的典型特征。部分肢端肥大症患者在接受葡萄糖注射后表现出反常的生长激素上升（GH-Par）。本研究旨在探究在葡萄糖负荷后GH-Par反应是否能表征非肢端肥大症患者。研究设计：在一家转诊中心进行的一项观察性病例对照研究。研究方法：招募了176名疑似肢端肥大症患者（特征为IGF-1水平升高，即GH谷值大于0.4 µg/L定义为肢端肥大症），以及55名匹配对照者（IGF-1水平正常且GH被抑制）。定义GH-Par90min为葡萄糖摄入后最迟90分钟时GH峰值超过基础水平的120%。