a 3-year follow-up of optic neuritis phenotypes in Chinese cohort

This prospective study recruited patients with new-onset ON in Shanghai, China between January 2015 and March 2017, and patients were followed up for 3 years. Clinical characteristics and optical coherence tomography were evaluated among the myelin oligodendrocyte glycoprotein seropositive (MOG-ON), Serum aquaporin-4 seropositive (AQP4-ON), and double seronegative (seronegative-ON) groups. Outcomes included the best-corrected visual acuity (BCVA) and relapse rate. Peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were also measured.

本前瞻性研究于2015年1月至2017年3月期间在上海，中国招募了新发多发性硬化症（ON）患者，并对患者进行了为期3年的随访。研究评估了髓鞘少突胶质细胞糖蛋白血清阳性（MOG-ON）、血清水通道蛋白-4血清阳性（AQP4-ON）和双阴性（血清阴性-ON）组的临床特征和光学相干断层扫描。研究结果包括最佳矫正视力（BCVA）和复发率。同时，还测量了视盘周围视网膜神经纤维层（RNFL）和黄斑神经节细胞-内丛状层（GCIPL）的厚度。