Dataset from Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

Cholestasis is a condition in which bile is not properly transported from the liver to the
small intestine. Cholestasis can be caused by an array of childhood diseases, including the
genetic diseases Alagille syndrome (ALGS), alpha-1 antitrypsin (a-1AT) deficiency, bile acid
synthesis and metabolism defects, and progressive familial intrahepatic cholestasis (PFIC) or
benign recurrent intrahepatic cholestasis(BRIC). This study will investigate the natural
history and progression of the four previously mentioned cholestatic liver diseases to
provide a better understanding of the causes and effects of the diseases.