File S1 - Impact on Clinical and Cost Outcomes of a Centralized Approach to Acute Stroke Care in London: A Comparative Effectiveness Before and After Model

Table S1, Main data sources used to model health outcomes and volume of resource use. Methods S1, Further details of short-run model. Methods S2, Further details of long-run model. Methods S3, Deterministic and probabilistic sensitivity analysis. Figure S1, Movement of patients in the short-run cost-effectiveness model from stroke onset to 3 months after stroke onset. Table S2, EQ-5D utility scores and QALYs. Table S3, Unit Costs. Figure S2, Movement of patients in the short-run cost-effectiveness model from 3 months after stroke onset until up to 10 years after stroke onset. Table S4, Transition probabilities in long-run model. Table S5, Barthel Index categories at three months after acute stroke among those at home. Table S6, Parameters and distributions used in the probabilistic sensitivity analysis. Figure S3, Distribution of patients between states from stroke onset to 90 days after stroke: Before period. Figure S4, Distribution of patients between states from stroke onset to 90 days after stroke: After period. Figure S5, Distribution of patients between states from 90 days to ten years after stroke: Before period. Figure S6, Distribution of patients between states from 90 days to ten years after stroke: After period. Figure S7, Monte Carlo simulations of incremental cost per QALY gained of new London stroke service using 90-day time horizon. Figure S8, Monte Carlo simulations of incremental cost per QALY gained of new London stroke service using ten year time horizon. (PDF)