Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment in complex with an inhibitor Pj34

Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment in complex with an inhibitor Pj34 Descriptor: N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, Poly [ADP-ribose] polymerase 15 Authors: Karlberg, T, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC) Deposit date: 2009-02-26 Release date: 2009-03-24 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein. J.Biol.Chem., 290, 2015

人源多聚ADP-核糖聚合酶15（poly(ADP-ribose) polymerase 15）催化片段与抑制剂Pj34复合物的晶体结构
描述：配体为N²,N²-二甲基-N¹-(6-氧代-5,6-二氢菲啶-2-基)甘氨酰胺（N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE）以及多聚ADP-核糖聚合酶15（Poly [ADP-ribose] polymerase 15）
作者：Karlberg, T、Siponen, M.I、Arrowsmith, C.H、Berglund, H、Bountra, C、Collins, R、Edwards, A.M、Flodin, S、Flores, A、Graslund, S、Hammarstrom, M、Johansson, A、Johansson, I、Kotenyova, T、Moche, M、Nordlund, P、Nyman, T、Persson, C、Sagemark, J、Schutz, P、Thorsell, A.G、Tresaugues, L、Van Den Berg, S、Weigelt, J、Welin, M、Wisniewska, M、Schuler, H、结构基因组学联合会（Structural Genomics Consortium, SGC）
提交日期：2009-02-26
发布日期：2009-03-24
最后修改日期：2024-05-29
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.2 Å
引用文献：《多聚ADP-核糖聚合酶-13/锌指抗病毒蛋白无ADP-核糖基转移酶活性的结构基础》（Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein），《生物化学杂志》（J.Biol.Chem.），290卷，2015年