Despite significant efforts to improve therapies for acute myeloid leukemia (AML), clinical outcomes remain poor. Understanding the mechanisms that regulate the development and maintenance of leukemic

NIAID Data Ecosystem80

Broad transcriptional firing represses bactericidal activity in human airway neutrophils [Transcriptional_Blockage_CFASN_Neutrophils]. Broad transcriptional firing represses bactericidal activity in human airway neutrophils [Transcriptional_Blockage_CFASN_Neutrophils]

白细胞功能调控

囊性纤维化气道炎症

Neutrophils are often considered terminally differentiated and poised for bacterial killing. In chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive neutrophil presence a

NIAID Data Ecosystem60

CaMK2D is a critical regulator of coactivation of leukemia stem cell factors in acute myeloid leukemia.. CaMK2D is a critical regulator of coactivation of leukemia stem cell factors in acute myeloid leukemia.

白细胞功能调控

AML（急性髓系白血病）

Relapse is one of the biggest challenges in treating acute myeloid leukemia (AML) due to leukemia stem cells (LSCs) resisting chemotherapy, providing a cellular reservoir to form the basis for relapse

NIAID Data Ecosystem80

Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization

肠道微生物免疫轴

白细胞功能调控

The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we ident

NIAID Data Ecosystem80

Mgl2+ cDC2s coordinate allergic airway type 2 but not type 17 inflammation against fungal spores

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