BRD4 inhibitor GNE987 exerts anti-cancer effects in Neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood, which is derived from primordial neural crest cells. GNE987 is a newly developed von Hippel-Lindau tumor suppressor (VHL)-based pan-BET-targeting PROTAC, which can bind to the target proteins (BET proteins, including BRD2, BRD3, and BRD4) and recruit them to the ubiquitin/ proteasome system for selective degradation. However, the function of GNE987 has not been assessed in NB models so far. In the present study, RNA-seq analysis was performed to explore the effect of GNE987 on NB cells. mRNA profiles of SK-N-BE(2) cells treated with 10 nM or same volume DMSO for 24 h were generated by RNA sequencing, in double, using Illumina NovaSeq6000.