Peptide-Functionalized Organotin Sulfide Clusters
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https://figshare.com/articles/dataset/Peptide-Functionalized_Organotin_Sulfide_Clusters/3810645
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资源简介：
We report the first successful attachment
of peptides to tin sulfide
clusters. For proof of principle, H-l-Phe hydrazide and Boc-protected
dipeptide hydrazides (Boc-l-Ala-l-Ala hydrazide
and Boc-l-Val-l-Phe hydrazide) were reacted with
keto-functionalized tin sulfide clusters [(R1Sn)4S6] (A; R1 = CMe2CH2C(O)Me) and [(R1Sn)3S4Cl]
(B). In the first case, we obtained single crystals of
an amino acid functionalized Sn/S cluster, [R22Sn4S5] (1; R2 = (CMe2CH2C(Me)N2C(O)CH(CH2Ph)NC(Me)CH2CMe2), formed after inorganic cluster rearrangement
and intramolecular condensation of the amino acid ligand. By means
of NMR spectroscopic investigations and ESI/LIFDI mass spectrometry,
we demonstrate that both dipeptides are attached to B under retention of the original cluster architecture to yield [(R3Sn)3S4Cl] (2; R3 = CMe2CH2C(NNH-Ala-Ala-Boc)Me) and [(R4Sn)3S4Cl] (3; R4 = CMe2CH2C(NNH-Phe-Val-Boc)Me), as evident
from mass spectrometric data of their cations [(R3Sn)3S4]+ (2+) and
[(R4Sn)3S4]+ (3+).
创建时间：
2016-09-20
