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Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet in P53 -/- mice

ChEBI2015-10-24 更新2026-07-12 收录

乳腺肿瘤发生

营养与基因互作

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74294 数据链接链接失效反馈

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Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet in P53 -/- mice

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创建时间：

2015-10-24

PI3K/AKT信号通路

乳腺肿瘤发生

Activation of Akt by the phosphatidylinositol 3′-OH kinase (PI3K) results in the inhibition of proapoptotic signals and the promotion of survival signals (L. P. Kane et al., Curr. Biol. 9:601–604, 199

PubMed Central100

DataSheet1_The Unique Genetic and Histological Characteristics of DMBA-Induced Mammary Tumors in an Organoid-Based Carcinogenesis Model.pdf

类器官致癌模型

乳腺肿瘤发生

Here, we report a model system using in vitro 7,12-dimethylbenz[a]anthracene (DMBA; 0.6 μM)-treated mammary tissue-derived organoids generated from heterozygous BALB/c-Trp53 knockout mice to induce tu

NIAID Data Ecosystem50

Expression data from MMTV-PDK1 transgenic mice

乳腺肿瘤发生

PDK1信号通路

The role of PDK1 on mammary tumorigenesis and its interaction with PPARdelta, was assessed. Transgenic mice were generated in which PDK1 was expressed in the mammary epithelium. We used microarrays to

NIAID Data Ecosystem30

FGF Receptor and Wnt-1 Signaling Cooperate in Mammary Tumorigenesis. Mus musculus

乳腺肿瘤发生

信号通路

The fibroblast growth factor pathway is known to cooperate with the highly oncogenic Wnt/beta-catenin pathway in mouse models of breast cancer. To investigate the mechanisms involved in this cooperati

NIAID Data Ecosystem60

Gene expression changes in Mammary Luminal Progenitor cells after MEN1 silencing. Homo sapiens

乳腺肿瘤发生

MEN1基因功能

Female patients with multiple endocrine neoplasia type 1 are at increased risk to develop breast cancer. We analyzed gene expression after silencing of the MEN1 gene in primary human mammary luminal p

NIAID Data Ecosystem40

Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet in P53 -/- mice

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