Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells

This study includes 75 pregnant individuals, where associations between 37 endocrine disrupting chemical biomarkers and methylation intensities were assessed using multiple linear regression. Methylation intensities were quantified from cord blood mononuclear cells and cord blood. The DNA methylation profiles were generated using the Illumina Infinium HumanMethylation450 Beadchip that measured about 450,000 CpGs. We profiled the methylome from cord blood mononuclear cells and placenta tisse from up to 75 pregnant individuals. This study follows cross sections desgin where exposure biomarkers were quantified from maternal urine at the delivery visit.