Transcriptome profiling of HDF, HDMEC and HEK skin cells under high glucose stimulation by RNA sequencing

Diabetes mellitus (DM) is a chronic endocrine disease characterized by hyperglycemia and multiple severe complications. Early research found that the difficulty in healing of diabetic foot ulcers is associated with abnormal proliferation of fibroblasts and vascular endothelial cells, but the specific molecular mechanism is still unclear. In this article, transcriptomics studies were performed on specific cells in diabetic skin to analyze the molecular differences in diabetes from a single skin cell level. and treatment of diabetic foot ulcers.