Genome-wide expression analysis of high-growth and low-growth capacity human mesenchymal stem cells

Human mesenchymal stem cells (hMSCs) were stratified into high- and low-growth capacity groups according to their growth potential in vitro which correlated with potency as assessed by standard MSC characterization assays. Gene expression profiling was then performed to undertand transcriptome level differences between them. Total RNA obtained from the high- and low-growth capacity hMSCs at early passage was studied by microarray