BCL6 expression in AITL could be transcriptionally regulated

Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. However, little is known about the molecular pathogenesis of this disease. In this study, we performed a miRNAs expression profiling analysis of a series of 26 PTCL cases in order to find deregulated pathways or genes that could become therapeutic agents for PTCL patients. 26 PTCL and 4 reactive lymph node were hybridized on a 8 x 15K human miRNA one-color platform (Agilent) containing probes for 471 human miRNAs.