Analysis of aortic gene expression in mice with aortic dissection treated with colchicine

Colchicine is an alkaloid found in the plant Colchicum, which is currently used for the treatment of acute gout and familial Mediterranean fever, and is being considered for the treatment of a variety of cardiovascular diseases such as pericarditis, atrial fibrillation, and coronary syndromes due to its significant anti-inflammatory effects. Aortic dissection is a cardiovascular disease characterised by a tear in the intima and congestion of the vessel wall leading to vessel wall delamination, with a rapid onset and high lethality. This study investigated the role of colchicine in BAPN-induced aortic dissection in mice. Gavage administration of colchicine along with BAPN modelling for three weeks showed a significant decrease in morbidity and mortality, indicating that colchicine can inhibit the occurrence of aortic dissection in mice. 3-week-old C57BL/6J male mice were fed with chow diet, and BAPNwas mixed into the drinking water and dissolved at a concentration of 1 g/kg/day for 3 weeks. Mice were simultaneously gavaged with colchicine (200 μg/kg/day) or equivalent doses of saline.