Widiastuti2010 - Genome-scale metabolic network Zymomonas mobilis (iZM363)

Widiastuti2010 - Genome-scale metabolic
network Zymomonas mobilis (iZM363)

This model is described in the article:

Genome-scale modeling and in
silico analysis of ethanologenic bacteria Zymomonas
mobilis.

Widiastuti H, Kim JY, Selvarasu S,
Karimi IA, Kim H, Seo JS, Lee DY.
Biotechnol. Bioeng. 2011 Mar; 108(3):
655-665
Abstract:

Bioethanol has been recognized as a potential alternative
energy source. Among various ethanol-producing microbes,
Zymomonas mobilis has acquired special attention due to its
higher ethanol yield and tolerance. However, cellular
metabolism in Z. mobilis remains unclear, hindering its
practical application for bioethanol production. To elucidate
such physiological characteristics, we reconstructed and
validated a genome-scale metabolic network (iZM363) of Z.
mobilis ATCC31821 (ZM4) based on its annotated genome and
biochemical information. The phenotypic behaviors and metabolic
states predicted by our genome-scale model were highly
consistent with the experimental observations of Z. mobilis ZM4
strain growing on glucose as well as NMR-measured intracellular
fluxes of an engineered strain utilizing glucose, fructose, and
xylose. Subsequent comparative analysis with Escherichia coli
and Saccharomyces cerevisiae as well as gene essentiality and
flux coupling analyses have also confirmed the functional role
of pdc and adh genes in the ethanologenic activity of Z.
mobilis, thus leading to better understanding of this natural
ethanol producer. In future, the current model could be
employed to identify potential cell engineering targets,
thereby enhancing the productivity of ethanol in Z.
mobilis.

This model is hosted on
BioModels Database
and identified by:
MODEL1507180057.
To cite BioModels Database, please use:
BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models.

To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.