RNA-seq of whole blood from progressing SSc-ILD patients

To identifying new blood derived prognostic biomarkers of lung disease progression in systemic sclerosis patients, we performed RNA-seq on whole blood from progressing SSc-ILD patients and controls enrolled in the FaSScinate clinical trial or an independent cohort. Comparative gene expression profiling to identify genes associated with disease progression between stable and progressing patients based on change in percent predicted FVC or HRCT.