Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC68.109 isolated from a vaccinated COVID-19 convalescent

Crystal structure of MERS-CoV spike stem helix peptide in complex with Fab of broadly neutralizing antibody CC68.109 isolated from a vaccinated COVID-19 convalescent Descriptor: Antibody CC68.109 Fab heavy chain, Antibody CC68.109 Fab light chain, Spike protein S2' Authors: Liu, H, Wilson, I.A. Deposit date: 2022-06-24 Release date: 2023-01-25 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease. Immunity, 56, 2023

从接种新冠疫苗的COVID-19康复者体内分离的广谱中和抗体CC68.109的抗原结合片段（Fragment antigen-binding, Fab）与中东呼吸综合征冠状病毒（Middle East Respiratory Syndrome Coronavirus, MERS-CoV）刺突茎区螺旋肽形成复合物的晶体结构。描述项：抗体CC68.109 Fab重链、抗体CC68.109 Fab轻链、刺突蛋白S2'。作者：Liu, H.、Wilson, I.A.。提交日期：2022年6月24日。发布日期：2023年1月25日。最后修改日期：2024年11月13日。检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.89埃（Å）。引用文献：广谱抗S2中和抗体可抵御所有三种可引发致死性疾病的人类乙型冠状病毒。《免疫》（Immunity），第56卷，2023年。