THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1

The alpha3beta1 integrin is localized in cell-cell junctions of endothelial cells and this integrin is involved in regulating angiogenesis by interacting with thrombospondin-1 (TSP1). Alpha4beta1 integrin binds to the N-terminal pentraxin modules of TSP1 and stimulates chemotaxis and modulates T cell behavior both positively and negatively.

α3β1 整合素定位于内皮细胞的细胞间连接处，此整合素通过与其相互作用（与血栓生成素-1（TSP1）结合）参与调节血管生成。α4β1 整合素与 TSP1 的 N 端五聚素结构域结合，并正向和负向调节趋化性和 T 细胞的行为。