Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation
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https://figshare.com/articles/dataset/Accessing_Multi_Fluorinated_Piperidines_Using_Heterogeneous_Hydrogenation/13038217
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资源简介：
Fluorinated
piperidines are desirable motifs for pharmaceutical
and agrochemical research. Nevertheless, general synthetic access
remains out of reach. Herein, we describe a simple and robust cis-selective hydrogenation of abundant and cheap fluoropyridines
to yield a broad scope of (multi)fluorinated piperidines. This protocol
enables the chemoselective reduction of fluoropyridines while tolerating
other (hetero)aromatic systems using a commercially available heterogenous
catalyst. Fluorinated derivatives of important drug compounds are
prepared, and a straightforward strategy for the synthesis of enantioenriched
fluorinated piperidines is disclosed.
创建时间：
2020-10-16
