Gene ontology (GO) biological processes enriched by DRMD proteins upon the exposure to the rough VTRM1 and smooth 16 M B. melitensis strains.

Table 1 represents 84 proteins from the proteomic analysis (proteins with iTRAQ labeling) of the 149 proteins (proteins with and without iTRAQ labeling). We performed enrichment analyses based on Gene Ontology (GO) [83]. We separately analyzed rough and smooth strains as well as distinguished between proteins moving into or out of DRMDs. In both the scenarios IN and OUT we included proteins that did not change localization (0) due to the low number of iTRAQ-labeled proteins. Thus we consider four distinct scenarios: (1) VTRM1 IN + no change: 75 proteins, (2) VTRM1 OUT + no change: 50 proteins, (3) 16M IN + no change: 77 proteins, and (4) 16M OUT + no change: 49 proteins.Protein Key: ACTG1 = Cytoplasmic Actin 2; ACTB = cytoplasmic Actin 1; ATP13A1 = Probable cation-transporting ATPase 13A1; ATP5G2 = ATP synthase, mitochondrial; ARFGEF1 = Brefeldin A-inhibited guanine nucleotide-exchange protein 1; ARHGEF1 = Rho guanine nucleotide exchange factor 1; ADD2 = Beta-adducin; BRPF1 = Peregrin; CACNA1H = Voltage-dependent T-type calcium channel subunit alpha-1H; CALM1 = Calmodulin; DNAH1 = Dynein heavy chain 1; KDM5C = Lysine-specific demethylase 5C; KDM5D = Lysine-specific demethylase 5D; LAMA2 = Laminin subunit α-2; MYH9 = Myosin 9; MYL12A = Myosin regulatory light chain 12A; PELO = Protein pelota homolog; RAC 1 = Ras-related C3 botulinum toxin substrate 1; SCN4B = Sodium channel beta-4 subunit; SGSM 3 = Small G protein signaling modulator 3; SLC25A4 = ADP/ATP translocase 1; SPTBN4 = Spectrin beta chain, non-erythrocytic 4; TTN = Titin; TMSL3 = Thymosin beta-4-like protein 3; TUBB = α -Tubulin; TUBA1B = α-Tubulin 1B chain; USP6 = Ubiquitin carboxyl-terminal hydrolase 6; VDAC2 = Voltage-dependent anion-selective channel protein 2.Proteins marked by * did not translocate into or out of DRMDs but contributed to the enrichment of the corresponding GO biological process.