Estrogen receptor regulation of the social transcriptome

We investigated the gene regulatory network of the estrogen receptor in the preoptic region of dominant and subordinate male Astatotilapia burtoni. We compared dominant males receiving either an ER antagonist or vehicle control and seperately compared subordinate males receiving either an ER antagonist or control. 8.25% of all genes examined changed expression in DOMs in comparison to only 0.56% in SUBs. Two separate loops (one for dominant males and one for subordinate males) with dye-swap containing 16 arrays each from 2 sources (an ER antagonist treated animal or a vehicle treated animal)