SOAT can transport taurolithocholate-3-sulphate

The human SLC10A6 gene encodes a sodium-dependant organic anion transporter, SOAT. Highest expressions of the gene are in testis, placenta and pancreas. Unlike the other SLC10A gene products, SOAT shows no affinity for binding bile acids. However, SOAT is able to transport sulpho-conjugated bile acids such as taurolithocholate 3-sulphate (Geyer J et al, 2007). It can also transport the structurally similar sulphated steroids (not shown here), thus SOAT may play a role in delivery of these prohormones to testis, pancreas and placenta.

人类SLC10A6基因编码一种钠依赖性有机阴离子转运蛋白，即SOAT。该基因在睾丸、胎盘和胰腺中的表达量最高。与SLC10A基因的其他产物不同，SOAT对结合胆酸没有亲和力。然而，SOAT能够转运硫酸结合的胆酸，如taurolithocholate 3-硫酸盐（Geyer J等人，2007年）。它还能够转运结构类似的硫酸化类固醇（此处未展示），因此，SOAT可能在将这些前激素输送到睾丸、胰腺和胎盘的过程中发挥一定作用。