Concentrations of plasma eicosanoids in early-lactation dairy cows during the experimental period.

1LT: leukotriene; PG: prostaglandin; TX: thromboxane; HODE: hydroxyoctadecadienoic acid; HETE: hydroxyeicosatetraenoic acid; oxoODE: octadecadienoic acid.2Treatments: cows were given 0, 1.5, or 3.0 µg/kg body weight rbTNFα injections daily for the first 7 days of lactation, respectively.3No treatment by day interactions were significant except as noted.4Contrast between Control and rbTNFα treatments.5Contrast between 1.5 and 3.0 µg/kg rbTNFα treatments.6Pro-inflammatory class is the sum all of PGE2, PGF2, LTB4, LTD4, TXB2, 9-HODE, 13-HODE, 5-HETE, and 15-HETE concentrations [27].7Anti-inflammatory class is the sum of resolvin D1 and D2, protectin, lipoxin A4, 7-maresin 1, 9-oxoODE, and 13-oxoODE concentrations [27].*A significant treatment × time interaction was detected (PEicosanoids were measured on day 0, 1, 3, and 5 of treatment. Values are least squares means ± SEM, n = 10–11.