Data S1 - Grin1 Receptor Deletion within CRF Neurons Enhances Fear Memory

The raw data from the (A) baseline RTPCR experiments showing fold change data from Cre−/fGrin1+ and Cre+/fGrin1+ mice. (B) Baseline anxiety tests for Cre+/fGrin1+ and Cre−/fGrin1+ showing open field (time in center zone, distance traveled), plus maze (time in open arm, distance traveled) and shock reactivity (amplitude) data. (C) Raw fold change data from post fear conditioning RTPCR for Cre−/fGrin1+ and Cre+/fGrin1+ mice is shown for amygdala (Gria1, Creb1) and BNST (Gria1, Creb1 and Grin1). (D) Raw data from auditory fear conditioning of Cre−/fGrin1+ and Cre+/fGrin1+ mice is shown at baseline and over the 5 tone- shock pairings. Extinction training (E) and extinction testing (F) freezing data are shown for Cre−/fGrin1+ and Cre+/fGrin1+ mice including baseline. Data during tone presentation is grouped into 3 trial bins. (G) Raw data from auditory fear conditioning of LV pCRF-Cre/fGrin1+ and LV pCRF-GFP/fGrin1+ mice is shown at baseline and over the 5 tone- shock pairings. Extinction training (H) and extinction testing (I) freezing data are shown for LV pCRF-Cre/fGrin1+ and LV pCRF-GFP/fGrin1+ mice including baseline. Data during tone presentation is grouped into 3 trial bins.
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