Association between mild renal insufficiency, inflammatory status on initial admission, and 1-year mortality following ST-segment elevation myocardial infarction

The systemic inflammation tends to rise progressively as kidney function deteriorates. However, it remains unknown whether mild renal insufficiency affects inflammatory response at admission and subsequent clinical outcomes following ST-segment elevation myocardial infarction (STEMI). This study aimed to evaluate the joint, interaction, and mediation associations between estimated glomerular filtration rate (eGFR) and neutrophil-lymphocyte ratio (NLR) at initial admission with 1-year mortality following STEMI. Data from 5,594 consecutive STEMI patients at seven centers were collected (NCT04996901). Mildly reduced eGFR (60-89 mL/min/1.73m2) was associated with both elevated NLR and increased 1-year mortality (β 0.55, 95%CI [0.07-1.02], P = 0.024; HR 2.18, 95%CI [1.55-3.08], P