Measurements of rat behavior during open field, passive place avoidance and active place avoidance.

Rats received either sham- or moderate-CCI. Beginning one hour after surgery the rats received either saline, cyclosporine (CYCLO) simvastatin (SIM), progesterone (PROG), minocycline (MINO), n-acetyl cysteine (NAC) or MINO plus NAC. Seven days later all groups were tested on the hierarchy of three behavioral tasks. In the open field test, there was no effect of treatment on total distance traveled (F7,40 = 0.40, p>0.8). In passive place avoidance, there was no effect of treatment on either average distance over 4 trials or shock zone entrances (total distance, F7,40 = 0.67, p>0.6; entrances, F7,40 = 0.48, p>0.8). In massed active place avoidance testing on the 6th trial of the first day, there was no effect of treatment on speed (F7,40 = 0.44, p>0.8) or linearity (F7,40 = 0.25, p>0.9)). The number of shocks per entrance in CCI-saline treated rats was not changed by the drugs individually or in combination (F7,40 = 0.39, p>0.6). In contrast, there was a significant treatment effect with MINO or MINO plus NAC significantly improved time to first entrance (F4,35 = 26.7, p