Tissue-specific insulin resistance indices and fasting plasma insulin as predictors of total incident CVD events in the 5.9-Years METSIM prospective study, Kuopio, Finland.

Abbreviations: CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio; IR, insulin resistance; LDL-C low-density lipoprotein cholesterol.Cox regression analysis. HRs were calculated using standardized predictors (unit = one standard deviation). Individuals with previously or newly diagnosed type 2 diabetes and type 1 diabetes at baseline were excluded from the analyses, as well as individuals with myocardial infarction and stroke before the baseline. Bold font indicates statistical significance PP, unadjusted.Pa, adjusted for age, BMI smoking, physical activity, alcohol consumption and family history of type 2 diabetes, hypertension (diagnosis was based on drug reimbursement) and LDL-C at baseline.*Matsuda IR was calculated as: 10/Matsuda ISI.Tissue-specific insulin resistance indices and fasting plasma insulin as predictors of total incident CVD events in the 5.9-Years METSIM prospective study, Kuopio, Finland.