Expression data of subtypes of inflamed synovia from patients with rheumatoid arthritis

Microarrays were used to detail the global program of gene expression underlying differences in the organisation of inflammatory cells classified by the expression of the CD21L and IL-17A genes. Synovia were defined by the expression of the CD21L and IL-17A genes as determined by semi-quantitative PCR. Twelve synovia were obtained from 10 patients during joint replacement surgery for RNA extraction and hybridization on Affymetrix microarrays. Synovia were randomly selected from cohorts classified as CD21L+/IL-17A+ and CD21L-/IL-17A-. Two CD21L+/IL-17A+ synovia (P1-1 and P1-2) from one patient, and one CD21L+/IL-17A+ synovia (P4-1) and one CD21L-/IL-17A- synovia (P4-2) from another patient, were included to assess gene expression profiles in CD21L/IL-17A subtypes vs. individuals.