Time dependency of treatment effects, fully adjusted for the co-variates listed in Table 2.

* P** P#PThe interaction between modality and time is explored as a linear function of time on dialysis, and also a categorical one. Only results for home dialysis and PD are shown; home HD is not included since we did not identify any time dependency of effect. When modeling the treatment effect as a linear function of time, the point estimates in the later period indicate the additional change in effect during that period. For instance, the point estimates for home dialysis indicate a 19% reduction in mortality risk in the first 3 years, offset by an further 36% increase in relative risk in the period after three years for a total 10% increase in risk in the later period; explicitly, (1–1.36)*(1–0.81)+0.81 = 0.10. When modeling the treatment effect as a categorical function of time, the point estimates in the later period indicate the further change in effect during that period relative to the baseline category, in this case 0–1 years.