No effect of Lactobacillus rhamnosus GG on eradication of colonization by vancomycin resistant Enterococcus faecium or microbiome diversity in hospitalized adult patients

Multi-center, randomized, double-blind, placebo-controlled trial evaluating the efficacy of a four-week supplementation of Lactobacillus rhamnosus GG (LGG) in eliminating the gastrointestinal carrier-state of vancomycin-resistant Enterococcus faecium (VREfm) in hospitalized adults.The primary outcome of the study was the number of patients with cleared VREfm colonization at week four of the intervention. Secondary outcomes were clearance of VREfm colonization at weeks eight, 16 and 24, number of VREfm infections (isolated from non-intestinal foci), and changes in fecal microbiome diversity after the intervention.