Experimental and numerical data of neuronal networks grown on PDMS fractal topographical substrates

Data corresponds to spontaneous activity of neuronal populations grown on either a flat PDMS surface or on a fractal-based Sierpinski pattern that leads to a topographically modulated PDMS substrate. In the provided image of the pattern (Sierpinsky_carpet.jpg) the black regions correspond to 100-micrometer elevations relative to the white regions. Experimental data includes recordings from rat and mouse primary cultures grown on either flat or topographical surfaces of 6 mm diameter. Two developmental stages are considered: DIV 7 (young cultures) and DIV 12 (mature cultures). Numerical simulations data considers equivalent surfaces on a 2 mm diameter synthetic cultures with a population density of rho=400 neurons/mm^2. Two contrasting developmental stages are implemented by considering two average axonal lengths, L=0.25 mm and L=2.0 mm. Excitatory population accounted for 80% of the neurons, and inhibitory one for the remaining 20%. The corresponding average axonal lengths are set identically for excitation, L_e, and inhibition, L_i. Data structure:In all cases, data are provided as plain text files (CSV format) with the following structure: XXXX_ROIs.csv: First column corresponds to the ROI id (experiments) or neuron id (simulations); second and third columns correspond to the horizontal and vertical positions of the ROI or neuron in cartesian coordinates. For experiments, ROI positions are in pixels; for simulations they are in mm. Data in pixels can be convered to mm by knowing that the full width of the area occupied by the ROIs corresponds to 6 mm. YYYY_spikesData.csv: First column corresponds to the ROI id (experiments) or neuron id (simulations); second column corresponds to the time of activation in s. Here, the labels XXXX and YYYY define the experimental batch or the corresponding simulation condition.