Acute and long-term effects of mutant p53 in vivo [B cells]
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Acute and long-term effects of mutant p53 in vivo [B cells]
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2012-12-31
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Promotion of pancreatic cancer metastasis by mutant p53
The TP53 transcription factor is frequently mutated at later stages of epithelial cancers, indicating a possible role in their invasion and metastasis. Importantly, in most cases rather than a simple
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In the present study, we used a high-throughput small RNA deep sequencing followed by a systematic computational analysis to identify genome wide mutant p53R273H regulated miRNAs in both DNA damage de
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Transcriptional profiling of p53 mutants in KP LUAD cells. Transcriptional profiling of p53 mutants in KP LUAD cells
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A systematic p53 mutation library links differential functional impact to cancer mutation pattern and evolutionary conservation
The TP53 gene is frequently mutated in human cancer. Research has focused predominantly on six major “hotspot” codons, accounting for only ~30% of cancer-associated p53 mutations. To comprehensively c
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