DNA Methylation profiles of benzene hematotoxicity. Homo sapiens

To identify potential methylation biomarkers in occupationally benzene-exposed individuals and to elucidate mechanisms of benzene hematotoxicity. Overall design: Bisulfite converted DNA from peripheral blood mononuclear cells of four patients of chronic benzene poisoning, four workers exposed to benzene levels ranging from < 1 ppm and four health controls matched age and gender without benzene exposure samples was hybridized to the Illumina Infinium HumanMethylation450 BeadChip array.