Investigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells

ChEBI2010-12-31 更新2026-07-21 收录

端粒酶非端粒功能

细胞恶性转化

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-24097 数据链接链接失效反馈

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资源简介：

Investigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells

创建时间：

2010-12-31

Transcriptional profiling of NF-kB's Rel and RelA proteins

NF-κB

细胞恶性转化

Rel and RelA proteins were stably expressed in the chicken DT40 pre-B cell line and analyzed by transcription profiling to identify transformation-impacting genes regulated by NF-kB’s oncogenic v-Rel

NIAID Data Ecosystem80

Differentially expressed genes between oncogene-introduced wild-type and Atf4-/- cells

细胞恶性转化

细胞衰老调控

During oncogenic transformation, cells acquire genetic mutations that override the normal mechanisms regulating cellular proliferation. Excessive expression of activating transcription factor 4 (ATF4)

NIAID Data Ecosystem50

Chronic PFOA Exposure in vitro Causes Acquisition of Multiple Tumor Cell Characteristics in Rat Liver Cells. Chronic PFOA Exposure in vitro Causes Acquisition of Multiple Tumor Cell Characteristics in Rat Liver Cells

全氟辛酸研究

细胞恶性转化

Perfluorooctanoic acid (PFOA) exposure is linked with tumorigenesis in rats, mice, and potentially tumorigenic in humans. Here, we studied long-term PFOA exposure with an in vitro transformation model

NIAID Data Ecosystem20

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [DIP-seq]. p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [DIP-seq]

肿瘤表观遗传学

细胞恶性转化

The p300 lysine acetyltransferase (KAT) can function as an oncogene or a tumor suppressor in hematologic malignancies. We have identified a tumor suppressor role for p300 in myelodysplastic syndrome (

NIAID Data Ecosystem70

In vitro transformation of human bronchial epithelial cells by diesel exhaust particles

环境毒理学

细胞恶性转化

The potential of diesel exhaust particles (DEP) to transform human bronchial epithelial cells (HBEC3) was investigated and a stably transformed cell line (T2-HBEC3) was established. Short-term DEP exp

NIAID Data Ecosystem40

Investigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells

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