Cortical transcriptome analysis of Cyfip2 mutant mice

CYFIP2 is a component of the WAVE regulatory complex which regulates actin polymerization and branching in diverse cellular compartments. Recent molecular genetic studies identified mutations of CYFIP2 in patients with early-onset epileptic encephalopathy and microcephaly, suggesting that CYFIP2 may have some roles in embryonic brain development. To understand its functions in vivo at the molecular level, we performed RNA-seq analysis in embryonic Cyfip2 mutant mice. Overall design: Cortical transcriptome of embryonic day 18.5 wild-type and Cyfip2 mutant mice.