Catalytic, Highly Enantio, and Diastereoselective Nitroso Diels−Alder Reaction

This communication presents studies that nitroso Diels−Alder adduct has been furnished in uniformly high yield and high enantioselectivity using nitrosopyridine as a substrate and copper as a catalyst. The obtained Diels−Alder adduct was easily transformed to corresponding chiral amino alcohols without loss of enantioselectivity.

本研究通讯展示了利用亚硝基吡啶作为底物，铜作为催化剂，成功实现了硝基狄尔斯-阿尔德反应加成物的合成，该加成物具有均匀的高产率和优异的立体选择性。所获得的狄尔斯-阿尔德加成物能够轻易地转化为相应的手性胺醇，且不损失其立体选择性。