Monkey_template.nii

Here, we investigated the cerebral asymmetries using a combination of the optimized voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) protocols in monkeys. The study-specific MRI and DTI-based templates were created in 66 adult Macaca fascicularis, and the asymmetrical index of grey and white matter was subsequently examined. The VBM analysis detected the well-known frontal and occipital petalias and confirmed the presence of leftward asymmetry in the ventral frontal cortex. A marked leftward asymmetry of anterior superior temporal gyrus but not posterior portion were found. We also identified grey matter asymmetries in some regions that were not previously reported including rightward anterior cingulate, insular cortex and thalamus, and leftward caudate. In contrast, the results of TBSS analysis for the first time revealed the robust leftwards asymmetries of corpus callosum (splenium and body), internal/external capsule, and white matter in middle temporal gyrus, adjacent thalamus and amygdala whereas the rightwards in uncinate fasciculus, posterior thalamic radiation and cerebral peduncle.本研究结合优化后的基于体素的形态测量学（voxel-based morphometry, VBM）与基于纤维束的空间统计分析（tract-based spatial statistics, TBSS）方案，探究了猕猴的大脑偏侧化现象。研究针对66只成年食蟹猕猴（Macaca fascicularis）构建了专属的磁共振成像（MRI）与弥散张量成像（DTI）模板，随后对灰质与白质的偏侧化指数进行了检测。基于体素的形态测量学分析检出了已被报道的额叶与枕叶脑叶偏侧突起，并证实腹侧前额叶皮层存在左侧偏侧化现象；同时发现颞上回前部呈现显著的左侧偏侧化，而其后部并无此特征。本研究还在多个此前未被报道的脑区中发现了灰质偏侧化：包括前扣带回、岛叶皮层与丘脑的右侧偏侧化，以及尾状核的左侧偏侧化。与之相对，基于纤维束的空间统计分析结果首次揭示了胼胝体（压部与体部）、内/外囊、颞中回白质、邻近丘脑与杏仁核的显著左侧偏侧化；而钩束、丘脑后辐射与大脑脚则呈现右侧偏侧化。